2021 Fixture/Results
| Round | Date | Day | Opponent | Venue | Time | Result |
|---|---|---|---|---|---|---|
| 1 | 28th Feb | Sun | Essendon | Hangar | 10:30am | Saints (47) d Bombers (29) |
| 2 | 6th March | Sat | Collingwood | Victoria Park | 12:00pm |
Magpies (46) d Saints (24) |
| 3 | 13th March | Sat | Geelong | Deakin University (Waurn Ponds) | 2:00pm |
Cats (16) d Saints (8) |
| 4 | 21st March | Sun | Casey | Casey Fields | 10:30am | Casey (42) d Saints (17) |
| 5 | 27th March | Sat | Darebin | Wilson Storage Trevor Barker Beach Oval | 10:00am | Saints (67) d Darebin (7) |
| 6 | 10th April | Sat | Williamstown | Wilson Storage Trevor Barker Beach Oval | 10:00am | Saints (35) d Williamstown (25) |
| 7 | 17th April | Sat | Collingwood | Wilson Storage Trevor Barker Beach Oval | 10:00am | Collingwood (41) d Saints (26) |
| 8 | 23rd April | Fri | Western Bulldogs | VU Whitten Oval | 7:30pm | Bulldogs (34) d Saints (16) |
| 9 |
2nd May |
Sun | Hawthorn Hawks | Wilson Storage Trevor Barker Beach Oval | 10:00am |
Saints (44) d Hawks (32) |
| 10 | 8th May | Sat | Port Melbourne | ETU Stadium | 2:00pm | Saints (55) d Borough (28) |
| 11 | 15th May | Sat | Geelong | Wilson Storage Trevor Barker Beach Oval | 10:00am | Geelong (46) d Saints (35) |
| 12 | 23rd May | Sun | Western Bulldogs | Wilson Storage Trevor Barker Beach Oval | 12:00pm | Western Bulldogs (33) d Saints (27) |
| 13 | 30th May | Sun | North Melbourne | Wilson Storage Trevor Barker Beach Oval | 12:00pm | |
| 14 | 5th Jun | Sat | Carlton | Ikon Park | 1:00pm |